Man with ozempic injection needle

Why Do I have Acid Reflux after taking Ozempic?

Written by: Ved Shah

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Published on

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Time to read 3 min

If you’ve started taking Ozempic and suddenly noticed a burning sensation in your chest, a sour taste in your mouth, or increased burping, you’re not alone.


Acid reflux after Ozempic is common but uncomfortable. It’s a side effect of taking that cheat code medication.

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What is Ozempic?

Ozempic is a GLP-1 receptor agonist.


It mimics the effects of the naturally occurring hormone GLP-1. 


It’s used for a multitude of reasons:

  • Regulating blood sugar for type 2 diabetes
  • Slowing digestion for weight loss
  • Reducing cardiovascular risk by improving cholesterol
Ozempic injections

Why You Get Acid Reflux After Ozemic

There are a few reasons why Ozempic may trigger acid reflux.


They all make sense because of what Ozempic is doing to your body:


#1: Delayed Stomach Emptying


#2: Relaxation of the Lower Esophageal Sphincter (LES)


#3: Slow digestion of high-fat meals


#4: Ozempic too close to meals

Diagram of how ozempic affects your digestive system

Tips to Manage Acid Reflux after Ozempic

Here are some tips you should follow to manage the acid reflux:

#1: Eat Smaller, More Frequent Meals Throughout the Day

This prevents overfilling your stomach and allows for gradual digestion.

#2: Track and Avoid Trigger Foods

Common triggers include coffee, chocolate, citrus, and fried foods.

#3: Don’t Lie Down for 2+ Hours after Eating

Take advantage of gravity to prevent acid from moving up your esophagus.

#4: Adjust your Ozempic Injection Schedule (with advice of a doctor)

Time your Ozempic away from your large daily meals.

#5: Drink Water In Sips

Avoid chugging large amounts of water at once. Gradual sips will help with digestion without overwhelming your stomach.

When to Talk to a Doctor

If your acid reflux is severe, persistent, or comes with other symptoms (chest pain, difficulty swallowing, vomiting), you should contact your healthcare provider.


They may adjust your dosage or recommend medication to protect your esophagus.


Bottom Line 

Ozempic can slow digestion and change how your stomach handles food, which can lead to acid reflux. With some lifestyle adjustments, you can continue treatment and reduce your acid reflux.

Patient holding Ozempic injection

Key Takeaways

Ozempic slows digestion, which can cause acid reflux for some users.

Delayed stomach emptying and LES relaxation allow acid to move upward.

Common triggers include greasy, spicy, or acidic foods.

Lifestyle changes like smaller meals and avoiding lying down after eating can help.

Talk to your doctor if symptoms are severe or ongoing.

Frequently Asked Questions

How do you stop acid reflux on Ozempic?

Try eating smaller meals, avoiding trigger foods, and staying upright for a few hours after eating. If it persists, ask your doctor about adjusting your dose or adding reflux medication.

How to fix stomach issues from Ozempic?

Start slow with bland, low-fat foods, drink water throughout the day, and avoid overeating. Your body often adjusts in a few weeks, but persistent discomfort should be discussed with your provider.

How to stop acid reflux quickly?

Sip water, chew sugar-free gum to increase saliva, or take an over-the-counter antacid for fast relief.

What drink will stop acid reflux?

Warm water, chamomile tea, or a small amount of low-fat milk can help calm symptoms without triggering more acid.

How do you flush acid out of your stomach?

You can’t completely “flush” stomach acid, but staying hydrated, avoiding acidic foods, and eating alkaline snacks like bananas can help balance acidity over time.

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